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Table 1 List of ApoE variants used in this study

From: Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

ApoE Variant

Genetic modification

APOE3WT

-

APOE4WT

APOE3WT + C112R

APOE3M

APOE3WT + F257A/W264R/V269A/L279Q/V287E

APOE4M

APOE4WT + F257A/W264R/V269A/L279Q/V287E

APOE4M-W34A

APOE4M + W34A

APOE3M-AP

APOE3M + Δ1–23 residues

APOE4M-AP

APOE4M + Δ1–23 residues

APOE3M-AS

APOE3M + Δ1–23 residues + R38A/E45A/E49A/R145A

APOE4M-AS

APOE4M + Δ1–23 residues + R38A/E45A/E49A/R145A

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Molecular Neurodegeneration

ISSN: 1750-1326