Fig. 1
From: Sex specific molecular networks and key drivers of Alzheimer’s disease
Comparison of Differential Gene Expressed Gene (DEG) Signatures between female AD and female control and between male AD and male control. A Venn diagrams to show the numbers of DEGs identified in different groups of comparison: female AD versus female control (F_AD-F_Ctrl), male AD versus male control (M_AD-M_Ctrl), female AD versus male AD (F_AD-M_AD) and female control versus male control (F_Ctrl-M_Ctrl). Left: up-regulated DEGs; Right: down-regulated DEGs. B The most enriched functions/pathways for the DEGs identified between AD and the control in women (top) and men (middle), as well as between women and men (bottom). Functions/pathways in blue/red were enriched by the down/up-regulated genes in AD/women; X axes represented –log10 (false discovery rate: FDR). C Expression patterns of the top 15 DEGs identified in each of the four comparisons (AD versus control in each sex & female versus male in each diagnostic category). Colored bars on the left represented the DEGs identified in which comparison and whether there were overlaps among the different comparisons. Color bars on top represented the expression pattern of the genes in the corresponding sex/AD groups