Fig. 5
From: Sex specific molecular networks and key drivers of Alzheimer’s disease
Cell-type Specific Changes in the LRP10 OE Mouse Brains. A UMAP visualization showing clustering of single cells (left) and expression patterns of the cell type marker genes in each cell type (right). B Cell type proportion analysis for six brain cell types in each experimental group. C Microglia subtypes were identified using the DAM marker genes (left). UMAP visualization showing clustering of homeostatic versus DAM subclusters (right). D Microglial subtype proportion analysis in each experimental group. E LRP10-centered gene co-expression network in the female AD human brains was enriched with DEGs identified between LRP10 OE versus control female E4FAD mouse brains. Blue nodes were the DEGs between female E4FAD mice with LRP10 OE versus control conditions. Diamond Nodes were the AD risk genes identified from previous GWAS studies