Fig. 1

A Bar graph depicting age of onset and disease duration of 125 PSEN1 E280A cases (females = red, males = blue). The thick dotted line represents average age of onset (49.64 years old), thinner dotted lines represent -2 and + 2 standard deviations (± 12.04 years) from it, and the area between age of onset quartiles 25% and 75% is shaded in pale green. B heatmaps depicting normalized values taken from [10] and [11], for signal intensity from Aβ (green), pTau (red) and the ratio of pTau signal over Aβ signal (blue). “Resistant” refers to the PSEN1 E280A APOEch carrier, and “Resilience” to the RELN-COLBOS one. Studied areas were: middle frontal gyrus (MFG), superior temporal gyrus (STG), middle temporal gyrus (MTG), inferior temporal gyrus (ITG), hippocampus – CA (Hip-C), hippocampus—uncus (Hip-U), amygdala (Amy), insula (Ins), inferior parietal lobe (IPL), occipital cortex (OC), gyrus cinguli (GC), lenticular nucleus (LN), caudate nucleus (CN), thalamus (Tha), cerebellum (CB), mesencephalon / Pons (Mes/pons), medulla oblongata (MO). C scatterplot of brain weight (BrBw) at time of death according to age of onset of dementia (AoO) in 125 PSEN1 E280A cases. There is no correlation between these two variables. Note the wide distribution of BrBw, and the difference between BrBw in both protected cases