Fig. 1
From: The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap
Contributing conditions and potential mechanisms underlying the relationship between inflammation and Alzheimer’s disease. The outer circle specifies several acute and chronic conditions that have been hypothesized to influence risk for Alzheimer’s disease and related dementias. The inner circle specifies potential biological mechanisms by which acute and chronic inflammatory conditions may influence target cells within the brain, specifically microglia. The biological processes initiated by acute and chronic inflammatory conditions are hypothesized to converge on common signaling pathways that can in turn prime and activate microglia via the neuro-immune axis