Fig. 4

Genetically encoding GluA2(R) rescues various aspects of memory and learning in J20 mice. a GluA2^G/G and GluA2^G/G/J20 mice showed a significant improvement in the percentage of correct alternations as compared to J20 mice in the Y maze (n’s; WT = 24, GluA2^G/G = 20, J20 = 24, GluA2^G/G/J20 = 22). b No difference between all four genotypes in the discrimination between objects in the object recognition test (n’s; WT = 25, GluA2^G/G = 21, J20 = 28, GluA2^G/G/J20 = 22). c In the working memory version of the radial arm maze, all eight arms were baited. J20 mice exhibited a significant increase in the number of errors compared to all other genotypes, that was partially recovered in GluA2^G/G/J20 mice (n’s; WT = 14, GluA2^G/G = 10, J20 = 10, GluA2^G/G/J20 = 11). d In the reference memory version of the radial arm maze, three of the eight arms were baited. J20 mice exhibited increased number of errors as compared to all other genotypes (n’s; WT = 17, GluA2^G/G = 10, J20 = 8, GluA2^G/G/J20 = 12). Each value represents the mean ± the SD for bar graphs and SEM for line graphs *p < 0.05, **p < 0.01, ****p < 0.0001