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Table 1 Description of genotypes used in study. All mice are littermates from crossing Gria2tm1BViss mice with J20 mice

From: The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

Genotype

Genotype Description

WT

Wildtype for both transgenes

Gria2G/G

Homozygous for Gria2 targeted allele (aka: edited GluA2(R)) and wildtype for J20

J20

Wildtype for Gria2 and hemizygous for J20

Gria2G/G/J20

Homozygous for Gria2 targeted allele (aka: edited GluA2(R)) and hemizygous for J20