Table 4 Canonical pathways significantly enriched for top-ranked GWAS genes

Synaptogenesis signaling

Community

L / M

334

4.07 × 10^–6

EF / L

191

1.62 × 10^–4

EF / M

286

6.61 × 10^–4

Opioid signaling

Community

EF / L

191

8.13 × 10^–6

Amyotrophic lateral sclerosis signaling

All

EF / L

211

2.14 × 10^–5

Maturity onset diabetes of young signaling

All

EF / L

211

2.14 × 10^–5

Corticotropin releasing hormone signaling

Community

EF / L

191

3.39 × 10^–5

Dilated cardiomyopathy signaling

Community

EF / L

191

3.39 × 10^–5

Netrin signaling

Community

EF / L

191

3.39 × 10^–5

Neuronal nitric oxide synthase signaling in skeletal muscle cells

Community

EF / L

191

3.39 × 10^–5

Circadian rhythm signaling

Community

EF / L

191

5.62 × 10^–5

Insulin secretion signaling

Community

EF / L

191

5.62 × 10^–5

White adipose tissue browning

Community

EF / L

191

1.05 × 10^–4

Synaptic long-term depression

Community

EF / L

191

1.62 × 10^–4

Nitric oxide signaling in the cardiovascular system

All

EF / L

211

1.74 × 10^–4

GPCR-mediated nutrient sensing in enteroendocrine cells

Community

EF / L

191

2.63 × 10^–4

Protein kinase A signaling

Community

EF / L

191

2.63 × 10^–4

Hepatic fibrosis signaling

Community

EF / L

191

3.24 × 10^–4

GABA receptor signaling

Community

EF / L

191

3.98 × 10^–4

Endocannabinoid neuronal synapse

All

EF / L

211

4.68 × 10^–4

Type II diabetes mellitus signaling

All

EF / L

211

4.68 × 10^–4

GNRH signaling

Community

EF / L

191

5.25 × 10^–4

Cardiac hypertrophy signaling (enhanced)

Community

EF / L

191

6.92 × 10^–4

Gustation pathway

Community

EF / L

191

6.92 × 10^–4

Androgen signaling

All

EF / L

211

7.94 × 10^–4

Calcium signaling

All

EF / L

211

7.94 × 10^–4

Oxytocin signaling

All

EF / L

211

7.94 × 10^–4

G beta gamma signaling

All

EF / L

211

8.32 × 10^–4

AMPK signaling

All

EF / M

210

9.55 × 10^–4

Glutamate receptor signaling

All

EF / M

210

9.55 × 10^–4