Fig. 4

CSF protein modules correlate to race and clinicopathological phenotypes of AD. A Modules were clustered based on relatedness defined by correlation of protein co‐expression eigenproteins (indicated by position in height). There were three main clusters in the network: Groups 1, 2 and 3. Biweight midcorrelation (bicor) analysis of module eigenprotein levels with diagnostic measures of AD, including MoCA score, immunoassay Amyloid-beta_1-42 (Aβ₄₂), total Tau (tTau), phosphorylated Tau₁₈₁ (pTau₁₈₁), ratio measures of tTau/Aβ₄₂, diagnosis, whether the sample has APOE ε4 allele or not, and race. The strength of positive (red) and negative (blue) correlations are shown by a heatmap with annotated bicor correlations and associated p-values. B Eigenprotein values distributed by race and diagnosis of representative modules for each cluster. C Differentially expressed proteins (DEPs) from AD samples compared to controls, by module with Caucasian proteome on the left and African Americans on the right. The height of the bars represents the fraction of module member proteins that were also DEPs compared to controls. The bars are color coded by heatmap for average log₂ difference in abundance, where red represents an increase in abundance in AD, and blue represents a decrease in abundance in AD