Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease

Table 1 Cohort characteristics

	CT Cau (N=53)	CT AA (N=52)	p – value^a	AD Cau (N=47)	AD AA (N=51)	p – value^a
Characteristics
Sex	33 F, 20 M	33 F, 19 M	-	29 F, 18 M	32 F, 19 M	-
Age^b	65 ± 8	64 ± 8	0.8848	68 ± 9	68 ± 9	0.9998
MoCA^c	26 ± 2	25 ± 3	0.7559	16 ± 6	14 ± 6	0.2055
^*Aβ42^d	1195.2 ± 262.0	1021.4 ± 301.1	0.0021	558.2 ± 169.9	483.4 ± 151.8	0.4026
tTau^d	186.2 ± 61.6	158.5 ± 56.5	0.6573	423.7 ± 189.2	301.5 ± 134.8	< 0.0001
pTau181^d	16.6 ± 5.6	14.1 ± 4.9	0.7787	43.3 ± 20.8	30.1 ± 14.1	< 0.0001
tTau/Aβ42 ^d	0.14 ± 0.03	0.14 ± 0.03	0.9994	0.78 ± 0.31	0.66 ± 0.30	0.0850

Abbreviations: CT Control, AD Alzheimer’s disease, Cau Caucasian / White, AA African American / Black
^ap-values were calculated using one-way ANOVA with Tukey correction, bold indicates p < 0.05
^bAge in years. Values given as average ± standard deviation
^cMost recent Montreal Cognitive Assessment (MoCA) score. Values given as average ± standard deviation
^dAβ42, tTau, pTau181, and tTau/Aβ42 in pg/mL. Values given as average ± standard deviation
^*Aβ42 levels that reached saturation (1700 pg / mL) were excluded from calculations and analysis

ISSN: 1750-1326