Fig. 2

VCP regions, interaction sites, PTMs, and variants. a The domain organization, regions relevant to aggregation and interactions (amyloidogenic, low complexity, major sites for cofactor interaction), subcellular targeting (nuclear localization sequence, NLS), and PTMs with known impact on VCP localization or function are depicted. Sm, sumoylation; M3, tri-methylation; Ac, acetylation. b Likely disease-associated variants (neurodegeneration and other conditions) are depicted; they have been curated from ClinVar (NIH). The variants are linked to different diseases and disorders, such as neurodegeneration and cancer. c VCP variants linked to disease (red), with predicted consequences (blue), likely benign (light green), or with uncertain outcomes (dark green) are shown. The distribution of mutations appears on top of the table. b, c The variant amino acid residue is shown at the margins in the one letter code. * indicates nonsense mutations. The figure has been generated with information from multiple sources [135, 138, 139, 151, 152]