Fig. 3

VCP protein in different tissues, VCP transcripts in the nervous system, and VCP-associated diseases. a The abundance of the VCP protein is shown for different tissues and cell types (MSC, mesenchymal stromal cell; NK cells, natural killer cells; PBMC, peripheral blood mononuclear cell). The VCP gene expression in different parts of the brain and the distribution of the VCP protein throughout the human body are depicted [24, 271, 272]. b VCP disease associations with a minimum score of 0.500 are presented. They belong to different categories [273]. c Brain regions that are particularly affected by FTD, ALS, or PD are delineated in color. Not all of the regions altered by the disease are demarcated