Fig. 1
From: TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
TMEM106B deposits in diverse brain regions and neurodegenerative diseases with different structural isoforms. Neurodegenerative diseases show overlapped clinical manifestation. TMEM106B has been reported as a common risk gene among those representative diseases, especially in those in which TDP-43 deposits are the main proteinopathy in the brain. Recent studies identified homotypic intracellular TMEM106B amyloid deposits in diverse brain regions from subjects with neurodegenerative diseases. Based on cryo-EM, TMEM106B filaments structure has three isoforms (type I, type II, type III). AD: sporadic Alzheimer’s disease; FAD: familial Alzheimer’s disease; EOAD: sporadic early-onset Alzheimer’s disease; PA: pathological aging; CBD: corticobasal degeneration; LNT: limbic-predominant neuronal inclusion body 4R tauopathy; DLB: dementia with Lewy bodies; FTD: frontotemporal dementia; PSP: progressive superanuclear palsy; FTDP-17 T: familial frontotemporal dementia and parkinsonism linked to chromosome 17 caused by MAPT mutations; MSA: multiple system atrophy; PD: sporadic Parkinson’s disease; ARTAG: aging-related tau astrogliopathy; PDD: Parkinson’s disease Dementia; ALS: amyotrophic lateral sclerosis; AGD: argyrophilic grain disease; FPD: familial Parkinson’s disease; Reproduced with the permission of Schweighauser, M. et al., [9]