Fig. 4
From: TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
Overall description of TMEM106B related disease pathology. TMEM106B and lysosome dysfunction forms a vicious cycle. TMEM106B deficiency triggers abnormal lysosome manifestations in neuron: reduced number, abnormal localization at the axon initial segment or perinuclear space and a vacuole-like shape. TMEM106B abnormal aggregation also induces hypomyelination by oligodendrocyte, further activating microglia-related neuroinflammation, disrupting signal transduction and related physiological process and driving the cognitive, psychiatric, and motor lesions in diverse neurodegenerative diseases. Other risk factors like aging or GRN mutation also contribute to this cycle via affecting lysosome functions