Fig. 2
From: Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease
Scheme depicting cellular and molecular processes that happen at the level of the brain parenchyma, meningeal dura, and central nervous system (CNS)-draining cervical lymph nodes in the young and healthy state (illustrations to the left), or during aging and in Alzheimer’s disease (illustrations to the right). Amyloid beta, Aβ; antigen-presenting cells, APCs; border-associated macrophages, BAMs; cerebrospinal fluid, CSF; interferon-gamma, IFN-γ; interstitial fluid, ISF; major histocompatibility complex class II, MHC-II; neurovascular unit, NVU