Fig. 1
From: TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains
TDP-43 pathology accumulates in amygdala and hippocampus of AD-TDP. (A) Graphical overview of AD-TDP staging based on TDP-43 deposition pattern from amygdala (stage 1), followed by the hippocampus and occipitotemporal gyrus (stages 2–3), basal forebrain and ventral striatum (stages 4–5) and last in the frontal cortex (stage 6). Created with BioRender.com. (B) Quantification of pTDP-43 protein levels in cognitively normal controls (CN), AD and FTLD cohorts across three brain regions: amygdala, hippocampus, and frontal cortex (see Table 1), using an immunoassay (see Methods). Data are presented as mean ± SEM. Number of cases is included in the figures. Statistical analyses were performed by One-way ANOVA following Dunn’s multiple comparison tests: *P < 0.05, **P < 0.005, *** P < 0.0005, ****P < 0.0001, ns: not significant