Fig. 2

Boxplots of the biomarker levels in the different diagnostic groups. Inferential statistics were not used for group comparisons due to the small size of the individual groups. For the analyses pertaining to ¹¹C-PIB binding, APParc mutation carriers were excluded due to the known mutation-specific relative sparsity of fibrillar amyloid-β that causes exceptionally low ¹¹C-PIB binding levels. NC: non-carriers; pMC: presymptomatic mutation carriers; sMC: symptomatic mutation carriers; MCI-: MCI with a negative amyloid-β PET scan; MCI+: MCI with a positive amyloid-β PET scan; AD: Alzheimer’s disease dementia