Skip to main content
Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer’s disease with multi-modal PET and plasma GFAP

Fig. 6

Longitudinal trajectories of biomarker changes based on generalized additive mixed-effects modelling in ADAD mutation carriers. Regression plots comparing the longitudinal nonlinear trajectories of the different biomarkers in ADAD mutation carriers across the estimated time to expected symptom onset; the biomarker values are presented as standardised difference from non-carriers (NC) and the shaded areas depict the 95% confidence interval for each regression curve. The 11C-DED, 11C-PIB and 18F-FDG binding/uptake were quantified in the composite temporal, global cortical and temporoparietal ROIs, respectively. pMC: presymptomatic mutation carriers; sMC: symptomatic mutation carriers

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326