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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Fig. 6

Reversed lipid dysregulation in 5xFAD mice with KDS-5104 treatment. (a) qPCR analysis of Ppara, Cyp4a14, Tfeb and Mcoln1 in 4-month-old WT and 5xFAD mice treated with vehicle or KDS-5104 for 2 months (n = 9/group). (b) Heatmap representing z scores of top 55 dysregulated lipid species in 5xFAD mice identified by lipidomic analysis of 4-month-old WT and 5xFAD mice treated with vehicle or KDS-5104. (c) Normalized levels of the lipid species per lipid class (n = 5 mice/group). PE: phosphatidylethanolamine, PC: phosphatidycholine, PS: phosphatidylserine, DG: diglycerides, and TG: trigylcerides (TG). (d) Pie chart depicting the classes of the 156 lipids identified that are dysregulated in 5xFAD mice compared to WT and rescued with KDS-5104 treatment. CoQ: Coenzyme Q10, LPE: Lysophosphatidylethanolamine, SM: Sphingomyelin, and PI: Phosphatidylinositol. For all panels, data are presented as mean ± SEM. #p = 0.2 in (a) and 0.1 in (c), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. One way ANOVA with Tukey’s multiple comparisons tests as the post hoc analysis

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Molecular Neurodegeneration

ISSN: 1750-1326