Fig. 1

Proteins significantly correlated with age in human hippocampus. (A-B) Effect size estimates and 95% confidence intervals (horizontal bar) for proteins positively (A) or negatively (B) correlated with age at death (Q < 0.05) in linear regression models adjusted for PMI and sex. Proteins are grouped according to molecular functions from Uniprot. Proteins correlated with age in previously published ageing DLPFC datasets are indicated in red (Johns Hopkins Ageing cohort) and blue (Emory ADRC cohort) circles. (C) Protein set enrichment map of all significantly enriched categories from GSEA using curated protein sets from the molecular signatures database (MSIGDB, C2). Each node represents a significantly enriched protein set at Q < 0.05 that is increased (red) or decreased (blue) with age by the GSEA workflow. Protein sets with overlapping membership are connected by edges, where the thickness indicates the number of overlapping proteins. (D) Proteins that comprise specific nodes shown in (C). Nodes have been numbered to identify their position in the protein set enrichment map (C). Individual proteins that were significantly correlated with age at Q < 0.05 (A,B) are boxed