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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Fig. 4

TMEM106B levels are correlated with proteins involved in myelination and brain ageing. (A) Proteins correlated with TMEM106B in multiple regression adjusted for PMI, sex, and age. Proteins significant at Q < 0.05 are boxed and labelled. (B) Protein set enrichment map of selected significantly enriched categories from GSEA using curated protein sets from the molecular signatures database (MSIGDB, C2). Each node represents a significantly enriched protein set at Q < 0.05 that is negatively (blue) or positively (red) associated with TMEM106B levels. Protein sets with overlapping membership are connected by edges, where the thickness indicates the number of overlapping proteins. (C) Protein membership of specific nodes shown in (B). Nodes have been numbered to identify their position in the protein set enrichment map (B). Proteins that were significantly correlated with TMEM106B levels at Q < 0.05 are boxed

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Molecular Neurodegeneration

ISSN: 1750-1326