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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Fig. 5

TMEM106B rs1990622 genotype affects the hippocampal lipidome. (A-B) Heatmap of lipids that were significantly affected by rs1990622 genotype (NG/G=9, NA/G=20, NA/A=15), in individuals with APOE ε3/ε3 genotype. Each row represents a lipid that was significantly more abundant (A) or less abundant (B) in rs1990622-G/G individuals by ANOVA at Q < 0.05. (C-D) Top five lipid species that are more abundant (C) and less abundant (D) in rs1990622-G/G individuals ranked by P value. Lipids values are expressed as a molar % of total lipid. Cer: ceramide; DG: diacylglycerol; HexCer: hexosylceramide; Hex2Cer: dihexosylceramide; LPA: lysophosphatidic acid; LPC: lysophosphatidylcholine; PA: phosphatidic acid; PC: phosphatidylcholine; PE: phosphatidylethanolamine; PEp: phosphatidylethanolamine plasmalogen; PG: phosphatidylglycerol; PI: phosphatidylinositol; PS: phosphatidylserine; SM: sphingomyelin; ST: sulfatide; TG: triglyceride; CE: cholesterol ester

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Molecular Neurodegeneration

ISSN: 1750-1326