Fig. 7
Higher ST and Hex2Cer, and lower PE, in carriers of the protective rs1990622-G/G genotype. (A) Summary of changes in lipid class totals in rs1990622-A allele carriers (denoted as A+) relative to rs1990622-G/G homozygotes (APOE ε3/ε3 genotype only). Filled circles indicate lipid classes that differed significantly between the three rs1990622 genotypes (G/G, A/G, and A/A) by ANOVA, at Q < 0.05 (APOE ε3/ε3 genotype only; NG/G=9, NA/G=20, NA/A=15). (B) Lipid class totals as a function of rs1990622 genotype for the five lipids significant by ANOVA. F and P values are shown at the bottom of each plot and results of Tukey’s post-hoc comparisons are shown above (* P < 0.05, ** P < 0.01, *** P < 0.001). Cer: ceramide; HexCer: hexosylceramide; Hex2Cer: dihexosylceramide; ST: sulfatide; SM: sphingomyelin; S1P: sphingosine 1-phosphate; Sph: sphingosine; PA: phosphatidic acid; PC: phosphatidylcholine; PE: phosphatidylethanolamine; PEp: phosphatidylethanolamine plasmalogen; PG: phosphatidylglycerol; PI: phosphatidylinositol; PS: phosphatidylserine; LPA: lysophosphatidic acid; LPC: lysophosphatidylcholine; LPE: lysophosphatidylethanolamine; LPS: lysophosphatidylserine; Chol: cholesterol; CE: cholesteryl ester; DG: diacylglycerol; TG: triacylglycerol; AcCa: acylcarnitine