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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Fig. 8

Rs1990622 genotype does not significantly alter myelin protein levels. (A) Spearman’s correlation matrix between myelin proteins (blue labels) and lipid class totals (black labels). Asterisks show Bonferonni-corrected P values (* P < 0.05, ** P < 0.01, *** P < 0.001). (B) Myelin sheath proteins as a function of rs1990622 genotype. ANOVA F and P values are shown above each plot (none significant at P < 0.05 after correcting for false discovery rate). (C) Representative MBP immunostaining, and (D) % area of MBP staining in the CA1 region of the hippocampus of individuals that are homozygous for the rs1990622-G/G allele (n = 6) and carriers of the risk allele (rs1990622-A+, n = 6), aged 78–100. Lower images in (C) show high magnification images of boxed region (white box). CLDN11: Claudin-11; CNP: 2’,3’-Cyclic nucleotide 3’-phosphodiesterase; MAG: Myelin-associated glycoprotein; MBP: Myelin basic protein; MOG: Myelin-oligodendrocyte glycoprotein; OMG: Oligodendrocyte-myelin glycoprotein; PLLP: Plasmolipin; PLP1: proteolipid protein 1

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Molecular Neurodegeneration

ISSN: 1750-1326