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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

Fig. 4

Global simultaneous fits for fibril mass concentration using amyloid-binding dyes and soluble oligomer concentration. Fibril (top panels) and oligomer (bottom panels) concentrations were determined using amyloid-binding dyes and single molecule biophysical techniques, respectively. Fitting parameters are summarized herein and described in detail in ref. [186]. This study shows that it is possible to monitor oligomer dynamics from macroscopic amyloid-dye binding experiments. Reprinted from Dear et. al [186]

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Molecular Neurodegeneration

ISSN: 1750-1326