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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

Fig. 8

Consequences of the exposure of cells to misfolded protein oligomers. AFM cross-sectional profile of Aβ40 oligomers stabilized by Zn2+. Misfolded protein oligomers of this type typically are 2–6 nm in height, and they induce membrane binding and toxicity accompanied with deleterious changes to the properties of cell membranes, cellular responses, and changes to endogenous factors. The AFM map and cross-sectional profile were adapted from Limbocker et. al [337]. The membrane binding panel was adapted from Limbocker et. al [257]. Created with biorender.com

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Molecular Neurodegeneration

ISSN: 1750-1326