Fig. 2

Basal translatome differences in Apoer2^cKO and cleavage-deficient hippocampi. A, B Supervenn and heatmap depicting the overlap of transcripts significantly altered in Apoer2 transgenic mice compared to Apoer2^WT. A Translatome overlap of transcripts significantly (p-value< 0.05, |log₂FC|> 0.58) altered in the Apoer2 KI/cKO genotypes compared to Apoer2^WT. B Heatmap of the 53 translating SynGO (bolded) and disease-related transcripts (symbols) significantly altered in all three Apoer2 KI/cKO compared to Apoer2^WT. C Expanded translatome overlap of the ~3,000 transcripts altered in the Apoer2 KI/cKO genotypes compared to Apoer2^WT (|log₂FC|>0.58, p-value<0.05 in at least one). D Heatmap demonstrating the log₂FC of expanded basal translatome in Apoer2^cKO and cleavage-deficient hippocampi. E Enrichment analysis of the transcripts in Panel D. F Diagram depicting the SynGO transcripts differentially-translated in the Apoer2 KI/cKO (Panel D) compared to Apoer2^WT (up, red circles; down, blue circles) in the network from Fig. 1F. AD, Alzheimer’s disease; SCZ, schizophrenia; ASD, autism spectrum disorders; ID, intellectual disability