Fig. 4

Synaptic effects of Apoer2-ICD in Apoer2^cKO. A, B Diagrams depicting the transcripts differentially-translated in the Apoer2^cKO at baseline (Cre-only) compared to Apoer2^WT (up, red circles; down, blue circles) (A) or differentially-translated in Apoer2^cKO neurons expressing either ICD[+19] (plus-sign) or ICD[Δ19] (triangles) compared to the baseline Apoer2^cKO in the network from Fig. 1F (up, purple symbols; down, yellow symbols) (B). Note in Panel B, transcripts regulated by both ICDs in the same direction are depicted with circles and those differentially regulated by either the ICD[+19] or ICD[Δ19] are represented by plus-signs or triangles, respectively. C, D Heatmap displaying the log₂FC expression of the synaptic transcripts not represented in the networks in Panels A and B, respectively. *p<0.05, **p<0.01