Fig. 7
From: Regulation of the hippocampal translatome by Apoer2-ICD release
Apoer2-ICD regulation of AD GWAS and Reelin signaling transcripts. Heatmaps depicting the log2FC of translating AD GWAS (A) or Reelin signaling pathway (B) transcripts between the Apoer2cKO/KI neurons expressing only Cre or Cre with either Apoer2-ICD compared to Apoer2WT expressing only Cre (left panels of A,B) or between neurons expressing either ICD[+19] or ICD[Δ19] compared to the Cre-only translation within each genotype (right panels of A,B). B Reelin pathway transcripts are sorted into four groups: the core Reelin receptor complex and associated tyrosine kinases (1), the signaling pathway regulating cadherin trafficking (2), the signaling pathway regulating tau (MAP1B) phosphorylation (3), and the other members of the canonical Reelin pathway (4). Significance is represented by the size of the node