Fig. 4
From: TDP-43 pathology is associated with increased tau burdens and seeding
AD(LATE-NC+) seeds impact TDP-43 nuclear clearance in TDP-43A315T mice, but not neuronal loss. a Immunohistochemistry with anti- C-terminal TDP-43 (405-414aa.) of mouse experimental groups in CA1-hippocampus and motor cortex. A group of age-matched, non-injected animals was included in this analysis (n = 7). AD(LATE-NC+) injected mice display neurons cleared of TDP-43 (arrowheads), scale bars = 50µm. Quantification of the percentage of neurons cleared for C-t TDP-43 of all experimental mouse groups in (b) CA1-hippocampus and (c) motor cortex. AD(LATE-NC+)-injected animals exhibit higher percentages of nuclear TDP-43 clearance compared to all other groups except FTLD-TDP in the CA1 and to all groups in the motor cortex. Quantification of neuronal density (displayed in neurons/mm2) show no relevant differences in the (d) CA1 or (e) motor cortex. Multiple linear regressions (least squares) were performed to compare TDP-43 nuclear clearance and neuronal density among groups