Fig. 5
From: TDP-43 pathology is associated with increased tau burdens and seeding
Most dementia cases exhibit either AD pathology, LATE pathology or a combination of the two. The majority of symptomatic AD cases present comorbid TDP-43 pathology, i.e., LATE-NC alongside Aβ plaques and tau tangles (up to 57% of AD cases [3, 46, 81]). “Pure” LATE-NC cases with no detectable Aβ plaques also exist (27% of older adults [7]), which can be demented or non-demented