Fig. 5

Panel 6 proteins successfully distinguishing FTD-GRN patients from controls and correlate with levels of CHI3L1. (A-B) ROC curve analysis indicating the diagnostic performance of panel 6 (AUC = 0.87, 95% CI = 0.64 to 1.0) to separate cohort participants as affected (FTD-GRN) versus not affected (CON). (C-E) Correlation analysis of CSF levels of panel 6 proteins and TREM2 (microgliosis), GFAP (astrogliosis), and CHI3L1 (also known as YKL-40, neuroinflammation) within (C) the entire ALLFTD cohort (n (ALLFTD) = 23)), within (D) the control group only (n (NC) = 12), and within (E) the symptomatic FTD-GRN group (n (FTD-GRN) = 11). CSF levels of TREM2 (microgliosis), GFAP (astrogliosis), and CHI3L1 (also known as YKL-40, neuroinflammation) are included based on the quantitative data obtained from LC-MS/MS analysis. Each cell is colored and labeled according to Spearman r value; Spearman r > 0.5 is normally considered to indicate a strong correlation, while Spearman r > 0.75 is considered to indicate a very strong correlation.* = p-value < 0.05, ** = p-value < 0.01, *** = p-value < 0.001, n.s. = non-significant. FDR was not considered for the presented visualizations