Fig. 3

CD36^−/− BM transplant in Tg2576 mice suppresses ROS production in BAM. Mice received an icv injection of FITC-dextran to label BAM and, 24 h later, the ROS marker DHE was injected into the jugular vein. The vascular marker DiO was injected transcardiacally at the end of the experiment. A BAM of WT → Tg2576 mice have more DHE signal than WT → WT. B The DHE signal is reduced in CD36^−/− → Tg2576 chimeras. C Quantification of the numbers of BAM in the BM chimeras studied showing no differences among groups (top). Quantification of the DHE signal demonstrating reduced signal in CD36^−/− → Tg2576 chimeras (bottom). RFU: relative fluorescent units. N = 5/group; two-way ANOVA with Tukey’s test; scale bar, 100 µm; data presented as mean ± SEM