Fig. 4

Deletion of CD36 in BAM reduces Aβ_1-40, but not Aβ_1-42 or amyloid plaque load, in 15-month-old Tg2576 mice. A SDS-soluble and FA-soluble (SDS-insoluble) Aβ_1-40 are reduced in CD36^−/− → Tg2576 compared with WT → Tg2576 chimeras. B Amyloid plaque load assessed by 4G8 immunocytochemistry. C Plaque number/mm² and percent of area occupied by plaques do not differ between WT → Tg2576 and CD36^−/− → Tg2576. N = 5/group; two-way ANOVA with Tukey’s test; data presented as mean ± SEM