Fig. 7
Aβ1-40 is cleared more effectively from cortex and striatum in CD36−/− mice than in WT mice. A Cy5-conjugated Aβ1-40 was injected into the somatosensory cortex of CD36−/− and WT mice. One hour later, the Cy5-Aβ1-40 fluorescence at the injection site was lower in CD36−/− than in WT mice. B Six-month-old CD36−/− and WT mice were injected with human Aβ1-40 into somatosensory cortex. One hour later, Aβ1-40 levels at the injection site were lower in CD36-/- mice, while Aβ1-40 levels in blood sampled from the superior sagittal sinus (SSS) or the heart were higher, suggesting more efficient Aβ1-40 tissue clearance. C Cy5-Aβ1-40 and FITC-labelled inulin were co-injected into the striatum of CD36−/− and WT mice. Thirty min later, the Cy5-Aβ1-40 fluorescence was lower in CD36−/− mice than in WT mice, while the FITC-inulin fluorescence, a reference signal, was not affected. Data were analyzed by the two-tailed unpaired T-test. Data presented as the mean ± SEM