Fig. 3

Enhancer and suppressor screens identify distinct and overlapping gene sets within, and between species. A Summary of three large-scale screens performed in S. cerevisiae. Human orthologs are shown on the right. Blue colour indicates that the gene function was protective, orange indicates gene function enhances toxicity. B Venn diagram showing overlap of genes recovered between yeast screens. C Physical interaction network of human orthologs of genes identified in C. elegans (pink) or D. melanogaster (blue) as modifiers of AD models. Network from Biogrid, 0.4 confidence, physical interaction subnetwork