Skip to main content
Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

Fig. 3

Functional analysis of DEPs in male APPPS1-21-CD11br mice (TMV). A Proteomic heatmap profiles with hierarchical clustering to represent the intensity values of the significant DEPs identified by pairwise comparative analysis between APPPS1-21-CD11br (TMV) and WT-CD11br (RM) male mice. B Protein–protein interaction (PPI) networks were constructed using STRING with DEPs in APPPS1-21-CD11br male mice. Nodes represent proteins, edges represent interactions between two proteins. Proteins containing single node and not involved in the network are not included. C Significant terms from GO Biological Process (a) and Molecular Function (b) associated with Functional enrichment analysis of upregulated (red) and downregulated (blue) DEPs that form PPI network. D Significant protein clusters (a-d) identified by MCODE analysis of the PPI network of proteins. E KEGG (a) and Reactome (b) pathway enrichment analysis using STRING to identify the significant pathways of DEPs from APPPS1-21-CD11br male mice (FDR > 0.05) that form PPI network

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326