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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

Fig. 4

Functional analysis of DEPs in ABX-treated male APPPS1-21- CD11br mice (TMA). A Proteomic heatmap profiles with hierarchical clustering to represent the scaled-intensity values of the significant DEPs identified by pair-wise comparative analysis between ABX-treated (TMA) and vehicle-treated male APPPS1-21-CD11br (TMV) mice in all biological replicates. B Protein–protein interaction (PPI) networks were constructed using STRING with DEPs in ABX-treated male APPPS1-21-CD11br mice. Nodes represent proteins, edges represent interactions between two proteins. Proteins containing single node and not involved in the network are not included. C Significant terms from GO Biological Process (a) and Molecular Function (b) associated with Functional enrichment analysis of upregulated (red) and downregulated (blue) DEPs that form PPI network. D Significant protein clusters (a-g) identified by MCODE analysis of the PPI network of DEPs in ABX-treated male AD mice. E KEGG (a) and Reactome (b) pathway enrichment analysis was done using STRING to identify the significant pathways of microglial proteins from ABX-treated APPPS1-21-CD11br male mice (FDR > 0.05) involved in PPI network

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Molecular Neurodegeneration

ISSN: 1750-1326