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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

Fig. 5

Functional analysis of DEPs in female APPPS1-21-CD11br mice (TFV). A Proteomic heatmap profiles with hierarchical clustering to represent the intensity values of the significant DEPs identified by pair-wise comparative analysis between APPPS1-21-CD11br (TFV) and WT-CD11br (RF) female mice in all biological replicates. B Protein–protein interaction (PPI) networks were constructed using STRING with DEPs in APPPS1-21-CD11br female mice. Nodes represent proteins, edges represent interactions between two proteins. Proteins containing single node and not involved in the network are not included. C Significant terms from GO Biological Process (a) and Molecular Function (b) associated with Functional enrichment analysis of upregulated (red) and downregulated (blue) DEPs that form PPI network. D Significant protein clusters (a-c) identified by MCODE analysis of the PPI network of DEPs in female AD mice. E KEGG (a) and Reactome (b) pathway enrichment analysis was done using STRING to identify the significant pathways of microglial proteins from APPPS1-21-CD11br female mice (FDR > 0.05) involved in PPI network

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Molecular Neurodegeneration

ISSN: 1750-1326