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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

Fig. 8

Effect of ABX-treatment on cecal metabolite abundances in APPPS1-21-CD11br mice at 7-weeks. Targeted GC–MS analysis of cecal metabolites in male and female APPPS1-21-CD11br mice treated with ABX or vehicle (n = 10 per group) tested by one-way ANOVA analysis. Statistical significance of the effect of treatment and sex on (A) SCFA metabolites and (B) Tryptophan metabolite levels were indicated as (adjusted p-val: p) *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns-not significant, based on Tukey’s Multiple comparison test. The concentrations of most abundant SCFAs acetate, propionate, butyrate, and succinate (A, panels a-d) and normalized relative abundances of less abundant metabolites valerate, amino valerate and Desamino-tyrosine (A, panels e–g) in male and female WT, AD mice treated with vehicle or ABX mice are shown. The concentrations of significantly altered tryptophan metabolites Kynurenine, Kynurenic acid, Indole-3-lactic acid, and PreQ1 are shown in B, panels a-c respectively

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Molecular Neurodegeneration

ISSN: 1750-1326