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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis

Fig. 4

Results for target SNP and PRS analysis. (A) Cox proportional HRs for genome-wide significant SNPs, and PRS on age at onset (AAO) of ALS. Estimated HRs are displayed with error bars corresponding to 95% CIs. Higher effect corresponds to earlier AAO. (B) Effect estimates from a linear regression model of AAO of ALS. Lower effect estimates correspond to earlier AAO. Effect estimates from linear regression are displayed with error bars corresponding to 95% CIs. (C) Differential AAO in patients with different PRS of AAO of ALS. “0” denotes the patients in the first quartile of the PRS distribution, while “1” denotes the patients in the last quartile of the PRS distribution. (D) ROC curves for prediction of early-onset ALS. The black curve was plotted with PRS of risk of ALS. The red curve was plotted with PRS of AAO of ALS.

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Molecular Neurodegeneration

ISSN: 1750-1326