Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

Table 1 Common CETP single-nucleotide polymorphisms and their impact on cardiovascular risk and Alzheimer’s Disease

CETP SNPs	Effect on CETP activity	Effect on cardiovascular risk	Effect on AD risk
rs247616 (C > T)	Unknown, but decreased CETP mRNA expression [127] and increased HDL [170]	Decreased CAD risk [171]	No association [172]
rs1800775 (-629C > A)	Decreased [132]	Mixed: Increased MI risk [131] Higher CAD risk [173] Reduced IHD, MI, ICVD, and IS risks [174]	Mixed: No association [175] Decreased in an APOE ε4 allele-dependent fashion. [176]
rs708272 (+ 279G > A) TaqIB	Decreased [132]	Mixed: Increased MI risk [131] Reduced MI [177] and coronary risks [132] No association with MI [130] and CVR [129]	Mixed: No association [137, 178] Increased in the Asian populations with APOE4 + [179]
rs1532624 (G > T)	Decreased [180]	Mixed: No association with CVR [129] Decreased CAD [171]	Unknown
rs7499892 (C > T)	Unknown, but decreased HDL [181]	Increased CVR [129]	No association [172]
rs5882 (A > G) I405V	Decreased [132]	Mixed: Increased risk of CAD [182] Decreased risk of CHD [183]	Mixed: No association [172, 175, 179] Increased [137, 143] Decreased [142]

MI myocardial infarction, IHD ischemic heart disease, ICVD ischemic cerebrovascular disease, IS ischemic stroke, CVR cardiovascular risk, CAD coronary artery disease, CHD coronary heart disease

ISSN: 1750-1326