Altered plasma protein profiles in genetic FTD – a GENFI study

Table 1 Demographic data of the cohort

	Non-carriers (NC)	Presymptomatic mutation carriers (PMC)	Symptomatic mutation carriers (SMC)	Total	p-value
No. of participants	276	280	137	693
Age, mean years (SD)	47 (14)	45 (12)	63 (9)	49 (14)	< 0.001^a
Females (%)	152 (55)	174 (62)	57 (42)	383 (55)	< 0.001^b
Mutated gene (%)				417 (60)
GRN		133 (48)	49 (36)
C9orf72		96 (34)	62 (45)
MAPT		51 (18)	26 (19)
Age at onset, mean years (SD)
GRN			61 (8)
C9orf72			60 (9)
MAPT			51 (8)

^aOne-way ANOVA (F(2,690) = 106.0, p = 7.13 × 10^–41). Differences in age between NC vs SMC and PMC vs SMC (Tukey multiple comparison post-hoc test). No difference between NC and PMC (p = 0.06)
^bPearson’s Chi-squared test. More females in NC and PMC compared to SMC (X²(1, N = 413) = 6.1, p = 1.3 × 10^–2) and X²(1, N = 417) = 14.9, p = 1.1 × 10^–4 respectively). No difference between NC and PMC (X²(1, N = 556) = 2.6, p = 0.1)

ISSN: 1750-1326