Table 2 Comparison of plasma protein levels in symptomatic mutation carriers versus non-carriers and presymptomatic mutation carriers

RPH3A*

2.68 × 10^–2

1.535 (1.228—1.919)

2.27 × 10–²

1.46 (1.177—1.811)

NPTX2

2.93 × 10^–2

1.499 (1.2—1.874)

3.52 × 10^–1

1.176 (0.964—1.433)

XPO5

3.73 × 10^–2

1.598 (1.216—2.1)

1.29 × 10^–1

1.322 (1.056—1.656)

RGS7BP*

3.73 × 10^–2

1.504 (1.181 – 1.915)

2.27 × 10^–2

1.619 (1.246 – 2.103)

APOE*

3.73 × 10^–2

1.532 (1.179—1.992)

3.94 × 10^–2

1.516 (1.165—1.972)

S100A12*

3.73 × 10^–2

1.5 (1.173—1.919)

3.94 × 10^–2

1.394 (1.126—1.725)

GLA

3.87 × 10^–2

1.605 (1.194—2.158)

4.25 × 10^–1

1.185 (0.938—1.498)

APOC1*

4.06 × 10^–2

1.627 (1.194—2.218)

3.94 × 10^–2

1.651 (1.2—2.271)

EIF4ENIF1

4.60 × 10^–2

1.503 (1.144—1.976)

3.31 × 10^–1

1.264 (0.976—1.636)

LCAT

4.60 × 10^–2

1.414 (1.128—1.773)

8.46 × 10^–2

1.336 (1.075—1.662)

C7

4.60 × 10^–2

1.49 (1.14—1.948)

3.08 × 10^–1

1.277 (0.981—1.663)

CHGA

4.60 × 10^–2

1.458 (1.132—1.877)

5.96 × 10^–2

1.436 (1.111—1.855)

ADAMTS1*

5.00 × 10^–2

1.404 (1.113—1.77)

3.11 × 10^–2

1.564 (1.198—2.04)

TFEB

7.47 × 10^–2

1.362 (1.082—1.715)

2.27 × 10^–2

1.555 (1.229—1.967)

LRRFIP2

7.47 × 10^–2

1.344 (1.079—1.674)

3.94 × 10^–2

1.44 (1.141—1.818)

LAMA2

9.31 × 10^–2

1.327 (1.057—1.667)

2.27 × 10^–2

1.57 (1.219—2.022)

IL1B

1.69 × 10^–1

1.308 (1.018—1.681)

3.94 × 10^–2

1.576 (1.173—2.117)