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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Blood platelet factor 4: the elixir of brain rejuvenation

Fig. 1

Overview of brain aging and rejuvenation in mice in a PF4-dependent manner. Reduced or increased levels of PF4 (blood platelet factor 4) lead to aging-associated neurodegeneration and brain rejuvenation in mice and potentially in humans, respectively. Administration of klotho, physical exercise, caloric restriction and/or senolytics increase PF4 levels, with beneficial effects on aging-associated neurodegeneration and brain rejuvenation

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Molecular Neurodegeneration

ISSN: 1750-1326