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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

Fig. 5

Chronic optogenetic stimulation of GABAergic neurons improved memory performance in APP mice. (A) Schematic diagram of the open field test. (B) The total distance traveled during open field test across conditions. (C) Time spent exploring the center or border zones. (D) Schematic diagram of fear conditioning test. (E) Percentage of time spent freezing during fear recall. (F) Schematic diagram of the Y-maze spontaneous alternation is shown. (G) Percentage of spontaneous alternation (% alternation) activities across conditions. (H) The number of total entries. All data are expressed as means ± standard error. The number of mice examined: n = 10 mice/group. *P < 0.05. n.s. not significant

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Molecular Neurodegeneration

ISSN: 1750-1326