Fig. 2

Overexpression of hα-syn induces motor and cognitive impairment. (A) Evaluation of motor impairment using the rotarod test 3-months post-AAV delivery. (B) Progression of animals’ performances on the rotarod test, evaluated at 1-month, 2-months, and 3-months post-AAV delivery. (C) Evaluation of the animals’ motor coordination using the gait test 3-months post-AAV delivery. (D) Progression of animals’ deficits on the gait test, evaluated at 1-month, 2-months, and 3-months post-AAV-delivery. (E) Evaluation of animals’ performance in the open field at 3- months post-AAV-delivery. (F) Progression of animals’ performances in the open field, evaluated at 1-month, 2-months, and 3-months post-AAV delivery. (G) Evaluation of animals’ performance in the training phase of the MWM test at 3-months post-AAV-delivery. (H) Evaluation of animals’ performance in the probe trial of the MWM test at 3-months post-AAV-delivery. The data are presented as the means ± s.e.m. (n = 6–10 mice per experimental condition). One-way ANOVA followed by Tukey’s multiple comparisons test; (A, C, E & H) * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.01 and **** p ≤ 0.0001. Two-way repeated measures ANOVA followed by Tukey’s multiple comparisons test; (B, D & F) $ p ≤ 0.05, $$ p ≤ 0.01, $$$ p ≤ 0.001 and $$$$ p ≤ 0.0001 versus control group; £ p ≤ 0.05 and ££ p ≤ 0.01 versus mTurq group; # p ≤ 0.05 versus baseline for each group; (G) * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.01 and **** p ≤ 0.0001. MWM: Morris water maze