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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease

Fig. 3

Association results of CSF sTREM2 at chromosome 6. A Top LocusZoom plots at chromosome 6 in European ancestry (EURs) for the sentinel SNP rs12664332 and bottom one is the secondary signal rs142232675 conditioning on the sentinel SNP. X-axis depicts genomic coordinates at chromosome 3 and y-axis denotes the negative log10-transformed P value for each genetic variant. B Forest plots of effect size estimated by cohort for rs142232675 p.D87N, rs75932628 p.R47H, and rs143332484 p.R62H. Heterogeneity P is 0.57 for rs75932628, 0.63 for rs142232675, and 1.0 × 10-1 for rs143332484 respectively. C Violin plots of CSF sTREM2 Z -score Residuals vs. genotype of rs142232675 p.D87N, rs75932628 p.R47N, and rs143332484 p.R62H

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Molecular Neurodegeneration

ISSN: 1750-1326