Fig. 2
From: Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease
Brain age estimates as a function of ADAD mutation status and progression. (A) Scatterplot of DBN-predicted brain age (after harmonizing across scanner and site differences) as a function of true chronological age. Lines and shaded regions reflect regression fits and confidence intervals derived from a linear regression model. Dashed line reflects perfect age prediction. (B) Violin plot of brain age gap (BAG) after correcting for chronological age. Dashed line reflects perfect age prediction. P values are derived from Wilcoxon tests using a false discovery rate (FDR) correction. (C) Scatterplot of age-corrected BAG as a function of EYO. Curves and shaded regions reflect regression fits derived from a generalized additive mixed model (GAMM) and simulation-based [59] simultaneous 83.4% confidence intervals for comparison of two groups [57, 58]. Horizontal dashed line reflects perfect age prediction. Vertical dashed line reflects EYO of 0. Vertical solid line reflects the earliest EYO at which MCs significantly differed from NCs, based on the simultaneous confidence intervals. Axis labels and outlier points have been censored to prevent unblinding of participant mutation-carrier status