Fig. 6

Discriminative accuracy of immunoassay- and mass spectrometry-derived p-tau concentrations for AD. ROC curves displaying discriminative accuracy of p-tau₁₈₁ (left), p-tau₂₁₇ (middle) and p-tau₂₃₁ (right) measured using immunoassays (yellow lines) and mass spectrometry (blue lines) for amyloid-PET positivity. A, D: ROC curves for entire TRIAD and BioFINDER-2 samples. B, E: ROC curves for amyloid-PET positivity in CU individuals only. C, F: ROC curves for amyloid-PET positivity for CI individuals only. The summary of all statistical comparisons is reported in Tables 5 and 6. MS = Mass spectrometry;; CI = Cognitively impaired; CU = Cognitively unimpaired